Optimal generation in structure-preserving power networks with second-order turbine-governor dynamics

Recently we have been exploring the role of passivity and the internal model principle in power network control in the presence of uncertainties due to unmeasured demand and supply. In this work we continue this line of research and extend our results to include more complex dynamics at the generation side. Namely, we study frequency stabilization by primary control and frequency regulation by optimal generation control, where we additionally incorporate second-order turbine-governor dynamics. The power network is represented by the structure-preserving Bergen-Hill model [1]. Distributed controllers that require local frequency measurements are proposed and are shown to minimize the generation costs. Asymptotic convergence is proven when the generators satisfy a local matrix condition. The effectiveness of proposed controllers is demonstrated in a case study

A Robust Consensus Algorithm for Current Sharing and Voltage Regulation in DC Microgrids

In this paper a novel distributed control algorithm for current sharing and voltage regulation in Direct Current (DC) microgrids is proposed. The DC microgrid is composed of several Distributed Generation units (DGUs), including Buck converters and current loads. The considered model permits an arbitrary network topology and is affected by unknown load demand and modelling uncertainties. The proposed control strategy exploits a communication network to achieve proportional current sharing using a consensus-like algorithm. Voltage regulation is achieved by constraining the system to a suitable manifold. Two robust control strategies of Sliding Mode (SM) type are developed to reach the desired manifold in a finite time. The proposed control scheme is formally analyzed, proving the achievement of proportional current sharing, while guaranteeing that the weighted average voltage of the microgrid is identical to the weighted average of the voltage references.Comment: 12 page

Improved Acid Stress Survival of Lactococcus lactis Expressing the Histidine Decarboxylation Pathway of Streptococcus thermophilus CHCC1524

Background: Degradative amino acid decarboxylation pathways in bacteria have diverse physiological functions. Results: A histidine decarboxylation pathway introduced in L. lactis improves acid stress survival, and synergy with the glycolytic pathway is demonstrated. Conclusion: The physiological benefit of the new pathway is strongly dependent on the properties of the host organism. Significance: Acquisition of the histidine decarboxylation pathway mimics successful horizontal gene transfer

Groupon, Inc.

Groupon’s CEO Andrew Mason made a terrible mistake when he refused to accept Google’s $6 billion dollar offer to acquire his company. About a year after its IPO in 2011, Groupon’s market capitalization was only$2.5 billion, and its main product was coming to be thought of as junk e-mail. The company has pursued growth through expanding into new services and products, with the goal of becoming an e-commerce platform that “locks in” the business of local merchants

Isolated eyelid closure myotonia in two families with sodium channel myotonia

Sodium channelopathies (NaCh), as part of the non-dystrophic myotonic syndromes (NDMs), reflect a heterogeneous group of clinical phenotypes accompanied by a generalized myotonia. Because of recent availability of diagnostic genetic testing in NDM, there is a need for identification of clear clinical genotype–phenotype correlations. This will enable clinicians to distinguish NDMs from myotonic dystrophy, thus allowing them to inform patients promptly about the disease, perform genetic counseling, and orient therapy (Vicart et al. Neurol Sci 26:194–202, 2005). We describe the first distinctive clinical genotype–phenotype correlation within NaCh: a strictly isolated eyelid closure myotonia associated with the L250P mutation in SCN4A. Using clinical assessment and needle EMG, we identified this genotype–phenotype correlation in six L250P patients from one NaCh family and confirmed this finding in another, unrelated NaCh family with three L250P patients

Optical Coherence Tomography Angiography (OCTA) in Multiple Sclerosis and Neuromyelitis Optica Spectrum Disorder

Vascular changes are increasingly recognized as important factors in the pathophysiology of neuroinflammatory disease, especially in multiple sclerosis (MS). The relatively novel technology of optical coherence tomography angiography (OCTA) images the retinal and choroidal vasculature non-invasively and in a depth-resolved manner. OCTA provides an alternative quantitative measure of retinal damage, by measuring vascular density instead of structural atrophy. Preliminary results suggest OCTA is sensitive to retinal damage in early disease stages, while also having less of a "floor-effect" compared with commonly used OCT metrics, meaning it can pick up further damage in a severely atrophied retina in later stages of disease. Furthermore, it may serve as a surrogate marker for vascular pathology in the central nervous system. Data to date consistently reveal lower densities of the retinal microvasculature in both MS and neuromyelitis optica spectrum disorder (NMOSD) compared with healthy controls, even in the absence of prior optic neuritis. Exploring the timing of vascular changes relative to structural atrophy may help answer important questions about the role of hypoperfusion in the pathophysiology of neuroinflammatory disease. Finally, qualitative characteristics of retinal microvasculature may help discriminate between different neuroinflammatory disorders. There are however still issues regarding image quality and development of standardized analysis methods before OCTA can be fully incorporated into clinical practice

Differences in demographic traits of four butterflyfish species between two reefs of the Great Barrier Reef separated by 1,200 km

Author Posting. © The Author(s), 2011. This is the author's version of the work. It is posted here by permission of Springer for personal use, not for redistribution. The definitive version was published in Coral Reefs 31 (2012): 169-177, doi:10.1007/s00338-011-0838-z.Many species demonstrate variation in life history attributes in response to gradients in environmental conditions. For fishes, major drivers of life history variation are changes in temperature and food availability. This study examined large-scale variation in the demography of four species of butterflyfishes (Chaetodon citrinellus, C. lunulatus, C. melannotus, and C. trifascialis) between two locations on Australia’s Great Barrier Reef (Lizard Island and One Tree Island, separated by approximately 1200km). Variation in age-based demographic parameters was assessed using the re-parameterised von Bertalanffy growth function. All species displayed measurable differences in body size between locations, with individuals achieving a larger adult size at the higher latitude site (One Tree Island) for three of the four species examined. Resources and abundances of the study species were also measured, revealing some significant differences between locations. For example, for C. trifascialis, there was no difference in its preferred resource or in abundance between locations, yet it achieved a larger body size at the higher latitude location, suggesting a response to temperature. For some species, resources and abundances did vary between locations, limiting the ability to distinguish between a demographic response to temperature as opposed to a response to food or competition. Future studies of life histories and demographics at large spatial scales will need to consider the potentially confounding roles of temperature, resource usage and availability, and abundance / competition in order to disentangle the effects of these environmental variables.This work was supported by a National Science Foundation (USA) Graduate Research Fellowship (MLB) and by PADI Project A.W.A.R.E. (MLB).2012-11-1

Evidence of Two Functionally Distinct Ornithine Decarboxylation Systems in Lactic Acid Bacteria

Biogenic amines are low-molecular-weight organic bases whose presence in food can result in health problems. The biosynthesis of biogenic amines in fermented foods mostly proceeds through amino acid decarboxylation carried out by lactic acid bacteria (LAB), but not all systems leading to biogenic amine production by LAB have been thoroughly characterized. Here, putative ornithine decarboxylation pathways consisting of a putative ornithine decarboxylase and an amino acid transporter were identified in LAB by strain collection screening and database searches. The decarboxylases were produced in heterologous hosts and purified and characterized in vitro, whereas transporters were heterologously expressed in Lactococcus lactis and functionally characterized in vivo. Amino acid decarboxylation by whole cells of the original hosts was determined as well. We concluded that two distinct types of ornithine decarboxylation systems exist in LAB. One is composed of an ornithine decarboxylase coupled to an ornithine/putrescine transmembrane exchanger. Their combined activities results in the extracellular release of putrescine. This typical amino acid decarboxylation system is present in only a few LAB strains and may contribute to metabolic energy production and/or pH homeostasis. The second system is widespread among LAB. It is composed of a decarboxylase active on ornithine and L-2,4-diaminobutyric acid (DABA) and a transporter that mediates unidirectional transport of ornithine into the cytoplasm. Diamines that result from this second system are retained within the cytosol.